Facile synthesis of heteroaryl substituted $\gamma$-lactams from nitrovinyl arenes
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چکیده
منابع مشابه
Chemoenzymatic synthesis of enantiopure hydroxy sulfoxides derived from substituted arenes.
Enantiopure β-hydroxy sulfoxides and catechol sulfoxides were obtained, by chemoenzymatic synthesis, involving dioxygenase-catalysed benzylic hydroxylation or arene cis-dihydroxylation and cis-diol dehydrogenase-catalysed dehydrogenation. Absolute configurations of chiral hydroxy sulfoxides were determined by X-ray crystallography, ECD spectroscopy and stereochemical correlation. The applicatio...
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In the condensation of the 4and 5-nitro-substituted 2-acetyl-1,3-indandione with heteroaryl aldehydes in the presence of alkaline or acidic catalysts, the corresponding cinnamoyl derivatives are obtained that possess anticoagulant activity, compared with that of 2-acetyl-1,3-indandione. It has been proven that some of the sodium salts of the cinnamoyl-indandione possess anticoagulant activity. ...
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The FeCl3·6H2O-catalyzed three-component aza-Friedel-Crafts reaction of aromatic/heteroaromatic compounds, aromatic aldehydes and tert-butyl carbamate was reported. The subsequent Friedel-Crafts-type alkylation of the resulting tert-butyl diarylmethyl carbamate with heteroaromatic compounds under "open-flask" at room temperature was also performed. The two-step reaction was especially useful fo...
متن کاملFacile synthesis of optically active gamma-lactones via lipase-catalyzed reaction of 4-substituted 4-hydroxybutyramides.
Lipase-catalyzed transesterification of racemic 4-substituted 4-hydroxybutyramides with succinic anhydride proceeded enantioselectively to afford (S)-succinic acid monoester and unreacted (R)-4-hydroxybutyramide derivative, which were separated easily by treatment with an alkaline solution. Both enantiomers were converted easily to optically active gamma-substituted gamma-butyrolactones.
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ژورنال
عنوان ژورنال: TURKISH JOURNAL OF CHEMISTRY
سال: 2018
ISSN: 1300-0527,1303-6130
DOI: 10.3906/kim-1705-25